Neo-Penotran/Neo-Penotran Forte/Neo-Penotran Forte-L Special Precautions

Patients should be warned not to take alcohol during the therapy and for at least 2 days after the end of a course of treatment because of the possibility of disulfiram-like reactions.
High doses and long-term systemic use may cause peripheral neuropathy and convulsion.
The base contained in the vaginal suppository formulation may interact with certain rubber or latex products eg, those used in vaginal contraceptive diaphragms or condoms, therefore concurrent use is not recommended.
Sexual partners of patients with Trichomonas vaginalis should be treated at the same time.
Metronidazole dose must be reduced in renal failure.
In serious liver function failures, metronidazole clearance may be impaired. Metronidazole may increase encephalopathy symptoms due to increased plasma levels and therefore should be used carefully in hepatic encephalopathy patients. The daily dose of metronidazole must be reduced to ⅓ in patients with hepatic encephalopathy. The t_½ of lidocaine may be prolonged ≥2-folds in patients with impaired liver function. Impaired renal function does not affect the pharmacokinetics of lidocaine but may increase accumulation of metabolites.
Neo-Penotran/Neo-Penotran Forte/Neo-Penotran Forte L is not recommended for use in virgins.
Use in pregnancy & lactation: See Use in Pregnancy & Lactation section for further information.
Use in children: Neo-Penotran/Neo-Penotran Forte/Neo-Penotran Forte-L is not recommended for children.